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Infectious-inflammatory diseases caused by microorganisms sensitive to azithromycin, including bronchitis, pneumonia, skin and soft tissue infections, otitis media, sinusitis, pharyngitis, tonsillitis, and gonorrheal negonoreyny urethritis and / or cervicitis, Lyme disease (borreliosis).

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(dizziness). With simultaneous use of disturbed metabolism of cyclosporine, which increases the risk of side effects and toxicity caused by cyclosporin. General disorders: rarely - fatigue and chest pain. Caution should be exercised in the appointment of azithromycin in patients with severely impaired liver and kidney function. Antacids (aluminum and magnesium), alcohol and food slow down and reduce the absorption of azithromycin. Hypersensitivity (macrolides), liver and / or kidney failure, lactation, children under 12 years. With simultaneous use of digoxin or digitoxin with azithromycin may be a significant increase in the concentration of cardiac glycosides in plasma and the risk of glycoside intoxication. Hypersensitivity to macrolide-antibiotics. Disorders of the digestive.

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After discontinuation of treatment hypersensitivity reactions in some patients may persist, which requires specific therapy under medical supervision.

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The hearth high concentration of active substance inflammation azithromycin has a bactericidal effect. 25-1 g 1 time / day; children - 5-10 mg / kg, 1 time / day. Co CNS: dizziness, headache; rarely - drowsiness, weakness. FDA on an expedited basis of registered new drug for the treatment of gonorrhea. Increases concentration of digoxin at the expense of weakening its inactivation of the intestinal flora. In an application with disopyramide described the case of ventricular fibrillation.

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Azithromycin is inactive against Gram-positive bacteria resistant to erythromycin.

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With simultaneous use of azithromycin and warfarin are described cases of the last amplification effects. Slows down and increases the plasma concentration and toxicity of cycloserine, indirect anticoagulants, methylprednisolone, felodipine and drugs undergoing microsomal oxidation (carbamazepine, terfenadine, cyclosporine, geksobarbital, ergot alkaloids, valproic acid, disopyramide, bromocriptine, phenytoin, oral Aciclovir direct buy anaerobic bacteria: Bacteroides fragilis. Product: long-acting granules for oral suspension, tablets, film-coated, capsule, powder for oral suspension, lyophilizate for p-ra for infusion. Further observation revealed that these changes were reversible. azithromycin absorption is not significantly altered, while the use of antacids or blockers H2-histamine receptors, but it.

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